Propylamine → 2-(5-bromo-1,3-benzoxazol-2-yl)-4-nitro-N-propylaniline

反応式

[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:14]=3[N:15]=2)[C:7](F)=[CH:8][CH:9]=1)([O-:3])=[O:2].[CH2:21]([NH2:24])[CH2:22][CH3:23]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:11]2[O:12][C:13]3[CH:19]=[CH:18][C:17]([Br:20])=[CH:16][C:14]=3[N:15]=2)[C:7]([NH:24][CH2:21][CH2:22][CH3:23])=[CH:8][CH:9]=1)([O-:3])=[O:2]

参加物

反応物 2

HCID 7852Propylamine

HCID 218844392-(2-Fluoro-5-nitrophenyl)-5-bromobenzoxazole

生成物 1

HCID 53038022-(5-bromo-1,3-benzoxazol-2-yl)-4-nitro-N-propylaniline

実験手順

Prepared by the method of Example 54a), from 2-(3-nitro-6-fluorophenyl)-5-bromobenzoxazole (576 mg, 2.0 mmol) and propylamine (492 μL, 6.0 mmol) the subtitle compound was obtained. The product was used directly in the next step without purification.

出典と根拠

ORDレコード: ord-300b5a5a616c450a882ab83acdc36b93
出典データセット: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07138425B2

反応ノート

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