p-Toluenesulfonic acid monohydrate → 2-(3-Nitro-6-fluorophenyl)-5,7-dichlorobenzoxazole

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Reaction Steps

Prepared by the method of Example 15b), from N-(2-hydroxy-3,5-dichlorophenyl)-2-fluoro-5-nitrobenzamide (798 g, 2.3 mmol) and p-toluenesulfonic acid monohydrate (961 g, 5.1 mmol) the subtitle compound was obtained (597 mg, 79%). 1H NMR (DMSO) δ 9.00(t, 1H), 8.78(s, 1H), 8.24(dd, 1H), 7.97(s, 1H), 7.77(s, 1H), 7.09(d, 1H), 3.46(q, 2H), 1.73(m, 2H), 1.04(t, 3H).

Provenance & Evidence