p-Toluenesulfonic acid monohydrate → 2-(3-Nitro-6-fluorophenyl)-5-trifluoromethylbenzoxazole

HRID 722581노트

반응식

HRID 722581 반응식
O[C:2]1[CH:7]=[CH:6][C:5]([C:8]([F:11])([F:10])[F:9])=[CH:4][C:3]=1[NH:12][C:13](=[O:24])[C:14]1[CH:19]=[C:18]([N+:20]([O-:22])=[O:21])[CH:17]=[CH:16][C:15]=1[F:23].O.C1(C)C=CC(S(O)(=O)=O)=CC=1>>[N+:20]([C:18]1[CH:19]=[C:14]([C:13]2[O:24][C:2]3[CH:7]=[CH:6][C:5]([C:8]([F:10])([F:9])[F:11])=[CH:4][C:3]=3[N:12]=2)[C:15]([F:23])=[CH:16][CH:17]=1)([O-:22])=[O:21]

참가 물질

3

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 21884558N-(2-Hydroxy-5-trifluoromethylphenyl)-2-fluoro-5-nitrobenzamide

생성물 1

HCID 218845112-(3-Nitro-6-fluorophenyl)-5-trifluoromethylbenzoxazole

실험 절차

Prepared by the method of Example 15b), from N-(2-hydroxy-5-trifluoromethylphenyl)-2-fluoro-5-nitrobenzamide (667 g, 2.3 mmol) and p-toluenesulfonic acid monohydrate (961 g, 5.1 mmol) the subtitle compound was obtained (349 mg, 56%). 1H NMR (DMSO) δ 8.95(m, 1H), 8.56(m, 1H), 8.36(s, 1H), 8.12(d, 1H), 7.84(m, 2H).

출처 및 근거

ORD 기록
ord-370212266bb44c7e9cf3c4777e253dff
출처 데이터셋
uspto-grants-2006_11
특허 번호
US07138425B2

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