Hydrochloric Acid → HCID 21884536, compound

Participants

Reaction Conditions

Reaction Steps

A solution of lithium hydroxide (1.78 g, 65.0 mmol) in water (10 ml) was added to a solution of 2-(3-nitrophenyl)benzoxazole-6-carboxylic acid methyl ester (4.0 g, 14.8 mmol) in THF (30 ml). The reaction was heated to 60° C. for 4 h. The cooled reaction mixture was acidified with 2M HCl and the precipitate filtered, washed with water and dried under vacuum to give the subtitle compound (3.47 g, 92%). The product was used directly in the next step without purification.

Provenance & Evidence