3-Piperidinecarboxamide → HCID 21884479, compound

Participants

Reaction Steps

Prepared by the method of Example 76 g), from 2-[3-(6-chlorocarbonylbenzoxazol-2-yl)phenyl]-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid benzyl ester (50 mg, 0.09 mmol) and nipecotamide (18 mg, 0.14 mmol) the title compound was obtained (18 mg, 37%). 1H NMR (DMSO) δ 8.44(dd, 1H), 8.36(m, 2H), 8.29(dt, 1H), 7.95–7.76(m, 4H), 7.44(dd, 1H), 4.02(m, 1H), 3.18(bm, 2H), 2.87(bm, 2H), 1.70–1.38(m, 4H). MS 536.8 m/z (M−H)−.

Provenance & Evidence