Trimellitic anhydride → 2-[2-Methoxy-5-[5-(2-benzothiopheneyl)benzoxazol-2-yl]phenyl]-1,3-dioxo-2,3-dihydro-1h-isoindole-5-carboxylic acid

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Reaction Steps

Prepared by the method of Example 15f), from 2-(3-amino-4-methoxyphenyl-5-(2-benzothiophenyl)benzoxazole (120 mg, 0.32 mmol) and 1,2,4-benzenetricarboxylic anhydride (62 mg, 0.32 mmol) the title compound was obtained. (41 mg, 23%). 1H NMR (DMSO) δ 13.82(s, 1H), 8.46(dd, 1H), 8.38(d, 1H), 8.35(m, 2H), 8.18(d, 1H), 8.13(d, 1H), 8.00(d, 1H), 7.96(s, 1H), 7.85(m, 3H), 7.50(d, 1H), 7.40(m, 2H), 3.90(s, 3H). MS 547.2 m/z (M+H)+.

Provenance & Evidence