Trimellitic anhydride → HCID 21884371, compound

HRID 722631Notes

Reaction equation

[NH2:1][C:2]1[CH:3]=[C:4]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][C:22]([F:25])=[C:21]([F:26])[CH:20]=4)=[CH:15][C:13]=3[N:14]=2)[CH:5]=[CH:6][C:7]=1[O:8][CH3:9].[CH:27]1[C:32]([C:33]([OH:35])=[O:34])=[CH:31][C:30]2[C:36]([O:38][C:39](=O)[C:29]=2[CH:28]=1)=[O:37]>>[CH3:9][O:8][C:7]1[CH:6]=[CH:5][C:4]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([C:19]4[CH:24]=[CH:23][C:22]([F:25])=[C:21]([F:26])[CH:20]=4)=[CH:15][C:13]=3[N:14]=2)=[CH:3][C:2]=1[N:1]1[C:36](=[O:37])[C:30]2[C:29](=[CH:28][CH:27]=[C:32]([C:33]([OH:35])=[O:34])[CH:31]=2)[C:39]1=[O:38]

Participants

Reactant 2

HCID 11089Trimellitic anhydride

HCID 21884353HCID 21884353, compound

Product 1

HCID 21884371HCID 21884371, compound

Procedure

Prepared by the method of Example 1b), from 2-(3-amino-4-methoxyphenyl)-5-(3,4-difluorophenyl)benzoxazole (63 mg, 0.18 mmol) and 1,2,4-benzenetricarboxylic anhydride (35 mg, 0.18 mmol) the title compound was obtained (25 mg, 27%). 1H NMR (DMSO) δ 8.53(dd, 1H), 8.42(m, 3H), 8.18(m, 2H), 7.94(m, 2H), 7.79(dd, 1H), 7.60(m, 3H), 3.95(s, 3H). MS 527 m/z (M+H)+.

Sources & evidence

ORD record: ord-af3b7f1c7db943ae8902500d1ad17a96
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138425B2

Reaction notes

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