4-Chlorophenylboronic acid → HCID 21884368, compound

HRID 722638Notes

Reaction equation

HRID 722638 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2].[Cl:22][C:23]1[CH:28]=[CH:27][C:26](B(O)O)=[CH:25][CH:24]=1>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:26]4[CH:27]=[CH:28][C:23]([Cl:22])=[CH:24][CH:25]=4)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 742994-Chlorophenylboronic acidHCID 21884587HCID 21884587, compound

Product 1

HCID 21884368HCID 21884368, compound

Procedure

Prepared by the method of Example 15d), from 2-(3-nitro-6-methoxyphenyl)-5-bromobenzoxazole (400 mg, 1.14 mmol) and 4-chlorophenylboronic acid (269 mg, 1.71 mmol) the subtitle compound was obtained (323 mg, 74%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-791f5a8a2fdf4d6bb9554647ee82dcd8
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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