3-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride) → HCID 21884449, compound

HRID 722640Notes

Reaction equation

HRID 722640 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18](Br)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2].[Cl:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][C:28]=1[F:29]>>[N+:1]([C:4]1[CH:5]=[C:6]([C:12]2[O:13][C:14]3[CH:20]=[CH:19][C:18]([C:25]4[CH:26]=[CH:27][C:28]([F:29])=[C:23]([Cl:22])[CH:24]=4)=[CH:17][C:15]=3[N:16]=2)[C:7]([O:10][CH3:11])=[CH:8][CH:9]=1)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 27346603-Chloro-4-fluorophenylboronic Acid (contains varying amounts of Anhydride)HCID 21884587HCID 21884587, compound

Product 1

HCID 21884449HCID 21884449, compound

Procedure

Prepared by the method of Example 15d), from 2-(3-nitro-6-methoxyphenyl)-5-bromobenzoxazole (400 mg, 1.14 mmol) and 3-chloro-4-fluorophenylboronic acid (299 mg, 1.71 mmol) the subtitle compound was obtained (277 mg, 47%). The product was used directly in the next step without purification

Sources & evidence

ORD record
ord-c05340bb4db44f1fa1f3e226284ec249
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

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