Benzo[b]furan-2-boronic acid → 2-(2-Fluoro-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

HRID 722652Notes

Reaction equation

HRID 722652 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17](Br)=[CH:16][C:14]=2[N:15]=1.[O:21]1[C:25]2[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=2[CH:23]=[C:22]1B(O)O>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[CH:4][C:3]=1[C:11]1[O:12][C:13]2[CH:19]=[CH:18][C:17]([C:22]3[O:21][C:25]4[CH:26]=[CH:27][CH:28]=[CH:29][C:24]=4[CH:23]=3)=[CH:16][C:14]=2[N:15]=1

Participants

3

Reactant 2

HCID 2776266Benzo[b]furan-2-boronic acidHCID 218844392-(2-Fluoro-5-nitrophenyl)-5-bromobenzoxazole

Product 1

HCID 218842952-(2-Fluoro-5-nitrophenyl)-5-(2-benzofuranyl)benzoxazole

Procedure

Prepared by the method of Example 15d), from 2-(2-fluoro-5-nitrophenyl)-5-bromobenzoxazole (1.00 g, 3.0 mmol) and benzofuran-2-boronic acid (728 mg, 4.50 mmol) the subtitle compound was obtained (208 mg, 18%). The product was used directly in the next step without purification.

Sources & evidence

ORD record
ord-581c3a0b3f6146c993258d1992710140
Source dataset
uspto-grants-2006_11
Patent number
US07138425B2

Reaction notes

Loading…