Acrylic Acid → HCID 178460319, compound

HRID 722673Notes

Reaction equation

HRID 722673 reaction equation
[C:1]([OH:5])(=[O:4])[CH:2]=[CH2:3].[OH-].[Na+:7].[Na+].[C:9]([NH:13][NH:14][C:15]1[CH:16]=[C:17]([OH:24])[C:18](=[CH:22][CH:23]=1)[C:19]([O-:21])=[O:20])(=[O:12])[CH:10]=[CH2:11]>O>[C:1]([O-:5])(=[O:4])[CH:2]=[CH2:3].[Na+:7].[C:9]([NH:13][NH:14][C:15]1[CH:16]=[C:17]([OH:24])[C:18](=[CH:22][CH:23]=1)[C:19]([O-:21])=[O:20])(=[O:12])[CH:10]=[CH2:11].[Na+:7]

Participants

5

Reactant 3

HCID 6581Acrylic AcidHCID 14798Sodium Hydroxide2×HCID 67374215HCID 67374215, compound

Product 1

HCID 178460319HCID 178460319, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A mixture of acrylic acid (80.9 g) and deionized water (114 g) in a 500 mL beaker equipped with a magnetic stirrer is cooled to 7–10° C. and a 50% solution of sodium hydroxide in water (92 g) is added dropwise over 30 minutes while maintaining the reaction mixture temperature below 15° C. After the addition of sodium hydroxide, powdered N-acryloyl-4-amino salicylic acid (19 g, prepared as described in Example 11) is added and the mixture is stirred to form a homogenous solution.

Workup

  1. custombeaker equipped with a magnetic stirrer
  2. temperatureis cooled to 7–10° C.
  3. temperaturewhile maintaining the reaction mixture temperature below 15° C
  4. additionis added
  5. customto form a homogenous solution

Sources & evidence

ORD record
ord-4f087e2fc88f434fab711eba85919015
Source dataset
uspto-grants-2006_11
Patent number
US07138472B2

Reaction notes

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