HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Aminovaleric acid → 6-(Tert-butoxy)-6-oxohexanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Aminovaleric acid | HCID 138 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile | HCID 93865 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(Tert-butoxy)-6-oxohexanoic acid | HCID 15908937 | 52.7% |
Reaction Steps
Prepared as described for L3 from stirring 5-aminopentanoic acid (3.40 g, 29.1 mmol) in 50% aqueous dioxane with triethylamine (6.0 mL, 43.1 mmol) and BOC-ON (7.91 g, 32.1 mmol) to yield a cream solid (3.10 g, 48.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138520B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-0823345e1dc540b29bdcfc05b5e54da5 |
| Source note | uspto-grants-2006_11 |