HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 3-Methyl-2-phenylbutyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 3-Methyl-2-phenylbutanoic acid | HCID 19024 | — |
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Methyl-2-phenylbutyryl chloride | HCID 12394396 | — |
Reaction Steps
To a stirred solution of 3-methyl-2-phenylbutyric acid (891 mg; 5.0 mmol) and a catalytic amount of dry dimethylformamide (ca. 10 uL) in 10 mL of dry methylene chloride under nitrogen at room temperature was added oxalyl chloride (0.65 mL; 7.5 mmol) dropwise. After 1 hour, the mixture was concentrated in vacuo and used immediately for Step 2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138529B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-c3f7448e03b1410ea4fb4a4a4977ea14 |
| Source note | uspto-grants-2006_11 |