反应详情

Reaction of α-phenylcyclopentaneacetyl chloride (Prepared in Example 12, Step1) and 2-Amino-3-cyano-5,6-dihydro-4H-cyclopenta[b]thiophene (164 mg; 1.0 mmol) according to the procedure outlined in Example 5 for 20 h at room temperature provided after workup, crude product which triturated with diethylether to give 111 mg of which was further purified by recrystallization from ethylacetate/hexanes to provide 44 mg (%) of N-(3-Cyano-5,6-dihydro-4H-cyclopenta[b]thiophen-2-yl)-2-cyclopentyl-2-phenyl-acetamide as a light brown solid. EI-HRMS m/e calcd for C21H32N2OS (M+) 350.1453, found 350.1456.

1. customprovided after workup, crude product which
2. customtriturated with diethylether
3. customto give 111 mg of which
4. customwas further purified by recrystallization from ethylacetate/hexanes