Triacetoxyperiodinane → HCID 72408143, compound

Participants

Reaction Steps

7-[(Naphthalene-2-carbonyl)-amino]-6-oxo-1,3,4,6,7,8,11,11a-octahydro-2H-pyrido[1,2-a]azocine-4-carboxylic acid (1-hydroxymethyl-3-methanesulfonylamino-3-oxo-propyl)-amide, 117, (49 mg) is dissolved in 5 mL methylene chloride and cooled to 0 deg. Dess-Martin periodinane (90 mg) is added, and the reaction is strirred for 2 h at 0 deg. Saturated aqueous sodium bicarbonate solution is added and the mixture is extracted with ethyl acetate. The combined opganic layers are dried over sodium sulfate powder and the product is purified over silica (2% methanol in methylene chloride) to afford the desired product.

Provenance & Evidence