Hydrogen Peroxide → (S)-2-((R)-2-Methyl-butyl)-succinic Acid 4-tert-butyl Ester

Participants

Reaction Steps

To ester 112 (7.26 g, 0.018 mol) in H2O (53 mL) and THF (176 mL) at 0° C. was added a premixed solution of LiOH (37 mL of a 0.8 M solution) and H2O2 (10.57 mL of a 30% solution) and the solution warmed to room temperature. After 2 hours sodium bisulfite (7 g), sodium sulfite (13 g), and water (60 mL) was added and the two layers were separated and the aqueous layer extracted with ether. The combined organic phases were concentrated to an oil that was dissolved in heptane (200 mL). The resultant solid was filtered off and the filtrate dried (MgSO4) and concentrated to afford an oil (4.4 g) that was used without further purification.

Provenance & Evidence