Methanol → HCID 57032193, compound

HRID 722867Notes

Reaction equation

HRID 722867 reaction equation
[C:1]([O:5][C:6](=[O:18])[CH2:7][C@@H:8]([CH2:14][N:15]=[N+]=[N-])[CH2:9][C@@H:10]([CH3:13])[CH2:11][CH3:12])([CH3:4])([CH3:3])[CH3:2].[CH3:19]O>[Pd]>[C:1]([O:5][C:6](=[O:18])[CH2:7][C@@H:8]([CH2:14][NH2:15])[CH2:9][C@@H:10]([CH3:13])[CH2:11][CH2:12][CH3:19])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 887MethanolHCID 57137408HCID 57137408, compound

Product 1

HCID 57032193HCID 57032193, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

A mixture of 125 (2.8 g, 10.4 mmol) and 10% Pd/C (1.0 g) in methanol (50.0 mL) was hydrogenated at 41 PSI for 96 hours. The solution was filtered to give 1.7 g of crude 126 which was used in the next step without further purification. MS, m/z (relative intensity): 244 [M+1H, 100%], 285 [M+1H+CH3CN, 25%].

Workup

  1. filtrationThe solution was filtered
  2. customto give 1.7 g of crude 126 which
  3. customwas used in the next step without further purification

Sources & evidence

ORD record
ord-8bc9182fa0764b10a8bb96a7f3da8c3a
Source dataset
uspto-grants-2006_11
Patent number
US07138542B2

Reaction notes

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