HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyano-4-isopropyl-heptanoic acid t-butyl ester → 4-(1-Isopropyl-butyl)-2-pyrrolidone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyano-4-isopropyl-heptanoic acid t-butyl ester | HCID 54409153 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-(1-Isopropyl-butyl)-2-pyrrolidone | HCID 21888426 | 102.3% |
Reaction Steps
3-Cyano-4-isopropyl-heptanoic acid t-butyl ester (0.8 g, 3.2 mmol) is reduced under 50 psi of H2 in MeOH containing TEA and Ra Ni. When the theoretical amount of H2 is taken up, the catalyst is removed by filtration, and the solvent is evaporated to give 0.6 g (100% yield) of 4-(1-isopropyl-butyl)-2-pyrrolidone as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07138542B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-c47e33cf8f5a48bf94e16839fbfd94c7 |
| Source note | uspto-grants-2006_11 |