1,1'-Carbonyldiimidazole → 5,6-Dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one

Participants

Reaction Steps

A suspension of 1,1′-carbonyldiimidazole in tetrahydrofuran was added to a solution of 1,2,3,4-tetrahydro-8-quinolineamine (10 g) obtained in Reference Example 130 in tetrahydrofuran (100 ml), and the mixture was stirred at room temperature at 4 hours. The reaction mixture was concentrated to give a brown solid (11 g). Further recrystallization from water-ethyl estate afforded the title compound as colorless crystals (10 g).

Provenance & Evidence