Monomethylamine methanol → HCID 58737232, compound

HRID 722953Notes

Reaction equation

[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:9]=[C:10]([S:17](Cl)(=[O:19])=[O:18])[C:11]2[O:15][CH2:14][CH2:13][C:12]=2[CH:16]=1)=[O:7].[CH3:21][NH2:22].CO>>[Cl:1][CH2:2][CH2:3][CH2:4][CH2:5][C:6]([C:8]1[CH:9]=[C:10]([S:17]([NH:22][CH3:21])(=[O:19])=[O:18])[C:11]2[O:15][CH2:14][CH2:13][C:12]=2[CH:16]=1)=[O:7]

Participants

Reactant 2

HCID 57454252Monomethylamine methanol

HCID 58737227HCID 58737227, compound

Product 1

HCID 58737232HCID 58737232, compound

Procedure

Using 5-(5-chloropentanoyl)-2,3-dihydro-1-benzofuran-7-sulfonyl chloride (5.06 g) obtained in Reference Example 69 and a 40% methylamine-methanol solution (2.6 g) according to the same method as that of Reference Example 66, the title compound was obtained as colorless crystals (4.82 g) having a melting point of 120 to 121° C.

Workup

customobtained in Reference Example 69

Sources & evidence

ORD record: ord-9256c0b14ecb4dc398dcfa5eb7fc908f
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138533B2

Reaction notes

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