Oxalic Acid → HCID 21887847, compound

HRID 722980Notes

Reaction equation

Cl.[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17].[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33]>>[C:31]([OH:36])(=[O:35])[C:32]([OH:34])=[O:33].[Cl:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13][CH2:14][CH2:15][C:16]([C:18]1[CH:19]=[C:20]2[C:25]3=[C:26]([CH2:28][C:29](=[O:30])[N:24]3[CH2:23][CH2:22][CH2:21]2)[CH:27]=1)=[O:17]

Participants

Reactant 2

HCID 971Oxalic Acid

HCID 21887313HCID 21887313, compound

Product 1

HCID 21887847HCID 21887847, compound

Procedure

Using 8-(5-{[2-(2-chlorophenyl)ethyl]amino}pentanoyl)-5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-2(1H)-one hydrochloride (205 mg, 0.5 mmol) obtained in Example 39 and oxalic acid (45 mg, 0.5 mmol) according to the same method as that of Example 360, the title compound was obtained as colorless crystals (221 mg) having a melting point of 161 to 163° C. (dec). elementary analysis as C24H27ClN2O2.C2H2O4 calculation value: C, 62.33; H, 5.83; N, 5.59. experimental value: C, 62.15; H, 6.00; N, 5.44.

Sources & evidence

ORD record: ord-7bce461ba0af4050ba67f11408c9c6c0
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07138533B2

Reaction notes

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