Anisole → HCID 178462129, compound

Participants

Reaction Conditions

Reaction Steps

The solution of 290 mg (0.227 mmol) of Boc-Lys(ClZ)-Arg(Tos)-Pro-Ala-Lys(ClZ)-OBzl (SEQ ID NO: 15), 1 ml of anisole and 2 ml of HF was stirred at 0° C. for 2 h. The reaction mixture was evaporated under reduced pressure to remove HF. To the residue 2 ml of HF were added and the solution was stirred at 0° C. for another 1 h. The reaction mixture was evaporated under reduced pressure to remove HF. The residue was triturated with ether and the resulted solid was purified on the Sephadex G-10 column. The collected fractions were lyophilized to provide 130 mg (96%) of the title compound. Mp. 168–170° C., FAB-MS (m/e) 599[M+H]+.

Provenance & Evidence