Anisole → L-Lysine, L-prolyl-L-alanyl-

Participants

Reaction Conditions

Reaction Steps

The solution of 280 mg (0.417 mmol) of Boc-Pro-Ala-Lys(ClZ)-OBzl, 1 ml of anisole and 2 ml of HF was stirred at 0° C. for 2 h. The reaction mixture was evaporated under reduced pressure to remove HF. To the residue 2 ml of HF were added and the solution was stirred at 0° C. for another 1 h. The reaction mixture was evaporated under reduced pressure to remove HF. The residue was triturated with ether and the resulted solid was purified on the Sephadex G-10 column. The collected fractions were lyophilized to provide 100 mg (75%) of the title compound. Mp. 150–152° C., FAB-MS (m/e) 315[M+H]+.

Provenance & Evidence