Ethanol hydrochloride → HCID 137195809, compound

HRID 72310Notes

Reaction equation

HRID 72310 reaction equation
C([NH:8][CH:9]([CH2:15][N:16]1[CH2:21][CH2:20][N:19]([C:22]2[C:23]3[CH:35]=[C:34]([CH3:36])[S:33][C:24]=3[NH:25][C:26]3[CH:32]=[CH:31][CH:30]=[CH:29][C:27]=3[N:28]=2)[CH2:18][CH2:17]1)[C:10]([O:12][CH2:13][CH3:14])=[O:11])(OC(C)(C)C)=O.[ClH:37].C(O)C>>[ClH:37].[ClH:37].[ClH:37].[NH2:8][CH:9]([CH2:15][N:16]1[CH2:17][CH2:18][N:19]([C:22]2[C:23]3[CH:35]=[C:34]([CH3:36])[S:33][C:24]=3[NH:25][C:26]3[CH:32]=[CH:31][CH:30]=[CH:29][C:27]=3[N:28]=2)[CH2:20][CH2:21]1)[C:10]([O:12][CH2:13][CH3:14])=[O:11]

Participants

3

Reactant 2

HCID 21887872Ethanol hydrochlorideHCID 1360372732-(N-Boc)amino-3-[4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazin-1-yl]-propionic acid, ethyl ester

Product 1

HCID 137195809HCID 137195809, compound

Procedure

A mixture of 2-(N-Boc)amino-3-[4-(2-methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperazin-1-yl]-propionic acid, ethyl ester, H, (50 mg, 0.096 mmole) and HCl/ethanol (1.25 M, 2 ml) was stirred overnight at room temperature. The solvent was evaporated, the residue was diluted with water and washed with diethylether. The aqueous solution was lyophilized. Yield of Compound 2—30 mg (60%).

Workup

  1. customThe solvent was evaporated
  2. additionthe residue was diluted with water
  3. washwashed with diethylether

Sources & evidence

ORD record
ord-33ee9ac533f041a3b49fa4b8154a07ad
Source dataset
uspto-grants-2014_09
Patent number
US08828993B2

Reaction notes

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