Trimethylsilyl iodide → HCID 21886219, compound

Participants

Reaction Conditions

Reaction Steps

[5-(3-{3′-[5-(tert-Butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-yl}-ureido)-pentyl]-phosphonic acid (0.058 g, 0.076 mmol), trimethylsilyl iodide (0.162 g, 0.756 mmol) and DCM [5 mL] were added to a flask and heated to 40° C. for 10 minutes. The reaction was removed from the heat bath and allowed to stir at room temperature for 1 hour. H2O [56 μL] was added to this solution and stirred for 1 hour. The reaction was concentrated in vacuo. MeOH [2 mL] and 20 wt. % HCl (aq.) [84 μL] were added to the concentrate and allowed to stir at room temperature for 18 hours. Reaction was concentrated in vacuo followed by reverse-phase HPLC [acetonitrile/water (0.01% TFA)] to yield the title compound. ESI-MS (m/z): Calcd. for C25H31N4O6PS3: 611.71 (M+H); found 611.0.

Provenance & Evidence