5-Bromopentanenitrile → STK366373

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromovaleronitrile (5.12 g, 30.0 mmol) in DMF (40 mL) was added potassium phthalimide (6.00 g, 32.4 mmol). The above suspension was heated at 60° C. for 16 h, concentrated, and partitioned between H2O and DCM. The DCM layer was separated, washed with H2O (3×) and brine, dried over Na2SO4, and concentrated to give the title compound (6.84 g, quantitative yield) as a white solid.

Provenance & Evidence