Dichloromethane → HCID 178501015, compound

Participants

Reaction Steps

A solution of [(4-{7-bromo-3-[5-(2-bromo-acetylamino)-2-fluoro-benzyl]-3H-benzoimidazole-5-sulfonyl}-5-methylsulfanyl-thiophen-2-yl)-imino-methyl]-carbamic acid tert-butyl ester ((Example 191: step a) 0.014 g, 0.017 mmol) in CH2Cl2 (2 mL) was treated with methyl 3-mercaptopropionoate (2.50 μL, 0.025 mmol) and stirred at room temperature 30 min. The reaction was diluted with CH2Cl2 and washed with water (1×10 mL). The organic layer was dried over MgSO4 and concentrated in vacuo to afford the product 3-[(3-{4-bromo-6-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-benzoimidazol-1-ylmethyl}-4-fluoro-phenylcarbamoyl)-methylsulfanyl]-propionic acid methyl ester (0.011, 85%) as a tan solid. C31H33BrFN5O8S4: 814.04 (M+1) found 814.70.

Provenance & Evidence