HRID72328

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2735700

N-Boc-1,3-propanediamine

C8H18N2O2

结构：NCCCNC(=O)OCc1cc(-c2ccc(OCc3ccccc3)cc2)no1

HCID46893646

未命名化合物

PRODUCTS

生成物

HCID46893646

未命名化合物

结构：CC(C)(C)OC(=O)NCCCNC(=O)OCc1cc(-c2ccc(OCc3ccccc3)cc2)no1

HCID66617446

未命名化合物

PROCEDURE

实验过程

{3-[3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethoxycarbonylamino]-propyl}-carbamic acid tert-butyl ester was synthesized using t-butyl N-(3-aminopropyl)carbamate in the same manner as in Example 121, and then a boc-deprotection of the compound was performed to synthesize (3-amino-propyl)-carbamic acid 3-(4-benzyloxy-phenyl)-isoxazol-5-ylmethyl ester as a desired compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-cad8b2fa9ee54ef980f9e32eee888155
来源数据集: uspto-grants-2014_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08828992B2
来源说明: uspto-grants-2014_09

反应 SMILES

[NH2:1][CH2:2][CH2:3][CH2:4][NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9].[CH2:13]([O:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]2[CH:31]=[C:30]([CH2:32][O:33][C:34](=[O:40])[NH:35][CH2:36][CH2:37][CH2:38][NH2:39])[O:29][N:28]=2)=[CH:23][CH:22]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[C:8]([O:7][C:6](=[O:12])[NH:5][CH2:4][CH2:3][CH2:2][NH:1][C:34]([O:33][CH2:32][C:30]1[O:29][N:28]=[C:27]([C:24]2[CH:25]=[CH:26][C:21]([O:20][CH2:13][C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)=[CH:22][CH:23]=2)[CH:31]=1)=[O:40])([CH3:9])([CH3:11])[CH3:10].[CH2:13]([O:20][C:21]1[CH:22]=[CH:23][C:24]([C:27]2[CH:31]=[C:30]([CH2:32][O:33][C:34](=[O:40])[NH:35][CH2:36][CH2:37][CH2:38][NH2:39])[O:29][N:28]=2)=[CH:25][CH:26]=1)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1