Glycidol → HCID 21872498, compound

HRID 723282Notes

Reaction equation

[C:1]1([C:7]2[NH:8][CH:9]=[CH:10][N:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH2:12]1[O:14][CH:13]1[CH2:15][OH:16]>>[C:1]1([C:7]2[N:11]([CH2:12][CH:13]([OH:14])[CH2:15][OH:16])[CH:10]=[CH:9][N:8]=2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

Reactant 2

HCID 11164Glycidol

HCID 695912-Phenylimidazole

Product 1

HCID 21872498HCID 21872498, compoundYield 72%

Procedure

The procedure of Synthesis Example 1 was repeated aside from using an equimolar amount of 2-phenylimidazole instead of imidazole and an equimolar amount of glycidol instead of ethylene oxide. There was synthesized 3-(2-phenyl-1H-imidazol-1-yl)-1,2-propanediol (yield 72%).

Workup

customThe procedure of Synthesis Example 1

Sources & evidence

ORD record: ord-c829f1c14cd94c7e9e02fc22d5f8d78d
Source dataset: uspto-grants-2006_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07141351B2

Reaction notes

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