Acetic Anhydride → HCID 21872627, compound

HRID 723294Notes

Reaction equation

HRID 723294 reaction equation
[N:1]1([CH2:10][CH2:11][OH:12])[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1.[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([O:12][CH2:11][CH2:10][N:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[N:3]=[CH:2]1)(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 2281312-(1H-Benzimidazol-1-yl)ethan-1-ol

Product 1

HCID 21872627HCID 21872627, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Conditions

Temperature
20 °C

Procedure

To a mixture of the crude 2-(1H-benzimidazol-1-yl)-ethanol and 500 g of pyridine, 122 g of acetic anhydride was added dropwise. In a nitrogen atmosphere, the reaction mixture was stirred at 20° C. for 10 hours. The reaction mixture was subjected to conventional aqueous work-up and then purified by vacuum distillation, obtaining 165 g of 2-(1H-benzimidazol-1-yl)ethyl acetate (boiling point 145° C./27 Pa, yield 87%).

Workup

  1. additionwas added dropwise
  2. distillationpurified by vacuum distillation

Sources & evidence

ORD record
ord-3f9789c4c1b744efb853d4df3d6d4131
Source dataset
uspto-grants-2006_11
Patent number
US07141352B2

Reaction notes

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