Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Benzimidazole | HCID 5798 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Propanol, 3-bromo-, 1-acetate | HCID 12235775 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 21872631 | HCID 21872631 | 70% |
Reaction Steps
In a nitrogen atmosphere, a mixture of 118 g of benzimidazole, 181 g of 3-bromopropyl acetate, 111 g of triethylamine, 2 g of sodium iodide, and 500 g of N,N-dimethylformamide was heated and stirred at 80° C. for 16 hours. The reaction mixture was subjected to conventional aqueous work-up and then purified by column chromatography, obtaining 3-(1H-benzimidazol-1-yl)propyl acetate (yield 70%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07141352B2 |
|---|
| Source dataset | uspto-grants-2006_11 |
|---|
| ORD ID | ord-5ea63fb43db24ffca6547c8221329ddd |
|---|
| Source note | uspto-grants-2006_11 |
|---|
