Methyl methoxyacetate → HCID 21872629, compound

Participants

Reaction Steps

In a nitrogen atmosphere, a mixture of crude 2-(1H-benzimidazol-1-yl)ethanol as prepared in Synthesis Example 1, 156 g of methyl methoxyacetate, 3.0 g of sodium methoxide, and 200 g of diglyme was heated under reflux for 20 hours while distilling off the methanol formed during the reaction. The solvent was distilled off in vacuo. The reaction mixture was subjected to conventional aqueous work-up and then purified by column chromatography, obtaining 2-(1H-benzimidazol-1-yl)ethyl methoxyacetate (yield 65%).

Provenance & Evidence