Formaldehyde → HCID 10450603, compound

Participants

Reaction Steps

To a solution of 4-Benzyl-6-methyl-8-piperazin-1-yl-4H-benzo[1,4]oxazin-3-one (140 mg, 0.42 mmol) in CH2Cl2 (5 ml) from Example 1 was added formaldehyde (37 wt % solution in water, 50 μl, 0.67 mmol) and NaBH(OAc)3. The solution was stirred with a magnetic stirrer at room temperature for 2 hours, and then partitioned between CH2Cl2 (20 ml) and saturated NaHCO3 solution (20 ml). The aqueous layer was extracted with CH2Cl2 (2×20 ml). After drying over MgSO4, the organic fraction was concentrated in vacuo to give 4-Benzyl-6-methyl-8-(4-methyl-piperazin-1-yl)-4H-benzo[1,4]oxazin-3-one as yellow solid. (140 mg, 95%) MS: (M+H)+352.

Provenance & Evidence