2-Bromobutane → HCID 21873384, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-[4-(2-dimethylaminoethoxy)phenyl]-3-(4-hydroxyphenyl)-1,3-dihydroimidazol-2-one (50 mg) in propionitrile (1 mL) was mixed with cesium carbonate (100 mg) and 2-butyl bromide (25 mg) and heated at 80° C. for 2 hours. The reaction solution was filtered and the concentrated. The residue was purified by preparative HPLC. The product with the molecular weight of 395.51 (C23H29N3O3); MS (ESI): 396 ([M+H]+), was obtained as hydrotrifluoroacetate in this way.

Provenance & Evidence