Potassium Hydroxide → HCID 21873507, compound

HRID 723364Notes

Reaction equation

HRID 723364 reaction equation
[CH:1]([NH:3][N:4]([C:20]1[CH:25]=[CH:24][C:23]([O:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:22][CH:21]=1)[C:5]([NH:7][C:8]1[CH:13]=[CH:12][C:11]([O:14][CH2:15][CH2:16][N:17]([CH3:19])[CH3:18])=[CH:10][CH:9]=1)=[O:6])=O.[OH-].[K+]>CO.O>[CH3:18][N:17]([CH3:19])[CH2:16][CH2:15][O:14][C:11]1[CH:10]=[CH:9][C:8]([N:7]2[CH:1]=[N:3][N:4]([C:20]3[CH:25]=[CH:24][C:23]([O:26][C:27]4[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=4)=[CH:22][CH:21]=3)[C:5]2=[O:6])=[CH:13][CH:12]=1

Participants

5

Reactant 2

HCID 14797Potassium HydroxideHCID 21873457HCID 21873457, compound

Product 1

HCID 21873507HCID 21873507, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

1-Formyl-2-(4-phenoxyphenyl)-4-[4-(2-dimethylaminoethoxy)phenyl]semicarbazide (60 mg) was added to a solution of potassium hydroxide (15 mg) in methanol (20 mL). After 4 hours at room temperature, the mixture was heated at 40° C. for 24 hours. After cooling, the reaction solution was diluted with water and extracted with ethyl acetate. The organic phase was dried and concentrated. The product with the molecular weight of 416.48 (C24H24N4O3); MS (ESI): 417 ([M+H]+), was obtained in this way.

Workup

  1. temperatureAfter cooling
  2. extractionextracted with ethyl acetate
  3. customThe organic phase was dried
  4. concentrationconcentrated
  5. customMS (ESI): 417 ([M+H]+), was obtained in this way

Sources & evidence

ORD record
ord-4cb4e821cb0b4ef08d1f44711a79ae6f
Source dataset
uspto-grants-2006_11
Patent number
US07141561B2

Reaction notes

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