Methanol → HCID 21873959, compound

Participants

Reaction Steps

A solution of 12.8 g 2-chloromethyl-3-methyl-8-pivaloylaminoimidazo[1,2-a]pyridine in 600 ml of dry methanol is refluxed for 5 h. The reaction mixture is concentrated in vacuo to half the volume. After addition of 200 ml of saturated sodium bicarbonate solution, the mixture is extracted with diethyl ether. The organic phase is washed with water and dried over anhydrous sodium sulfate. Removal of the. solvent in vacuo yields 12.5 g (99%) of the title compound (m.p. 104° C.).

Provenance & Evidence