Water → HCID 25186553, compound

Participants

Reaction Steps

A solution of (2-amino-6-(2-furyl)-5-nitropyrimidin-4-yl) 4-methylbenzenesulphonate (478 mg, 1.27 mmol) in dimethoxyethane (15 mL) was treated with triethylamine (0.531 mL, 3.81 mmol) and 2-pyridinemethylamine (0.393 mL, 3.81 mmol), stirred for 16 h, poured into water (100 mL) and the resulting solid was filtered to give the title compound (275 mg, 69%) as a yellow solid; NMR δH (400 MHz, CDCl3) 8.70–8.58 (2H, m), 7.70–7.66 (1H, m), 7.55–7.54 (1H, m), 7.28 (1H, d, J 8.0 Hz), 7.24–7.20 (1H, m), 7.07–7.06 (1H, m), 6.54–6.52 (1H, m), 5.26 (2H, br s) and 4.83 (2H, d, J 5.0 Hz); Retention time 1.44 min.

Provenance & Evidence