Acetyl chloride → HCID 9984384, compound

Participants

Reaction Steps

As described for the preparation of 27, the reaction of 26 (prepared from 264 mg of 25) with acetyl chloride and triethylamine gave the acetamide which was purified by silica gel chromatography with 5% MeOH-0.5%NH4OH—CH2Cl2 followed by crystallization from Et2OAc to give 73 mg of 29, a white solid; 1HNMR [300 MHz, (CD3)2SO] δ 1.81 (s, 3H), 2.45 (s, 6H), 2.93. 3.00 (s, s, 4H), 3.38 (t, 2H), 3.60 (s, 4H), 3.68 (dd, 1H), 3.85 (s, 2H), 4.06 (t, 1H), 4.69 (m, 1H), 4.88 (s, 2H), 6.94 (d, 2H), 7.06 (t, 1H), 7.16 (dd, 1H), 7.33 (d, 2H), 7.49 (dd, 1H), 8.24 (t, 1H).

Provenance & Evidence