HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 7-Benzyloxy-6-methoxy-3H-quinazolin-4-one | HCID 135404718 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(Benzyloxy)-4-chloro-6-methoxyquinazoline | HCID 10661998 | — |
Reaction Steps
A mixture of 7-benzyloxy-6-methoxy-3,4-dihydroquinazolin-4-one (20.3 g), thionyl chloride (440 ml) and DMF (1.75 ml) was heated to reflux for 4 hours. The thionyl chloride was evaporated under vacuum and the residue was azeotroped with toluene three times to give 7-benzyloxy-4-chloro-6-methoxyquinazoline.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07141577B2 |
| Source dataset | uspto-grants-2006_11 |
| ORD ID | ord-97481254b5dc438e8a0c8113bc87a38e |
| Source note | uspto-grants-2006_11 |