反应详情

4-Chloro-3-nitrobenzoic acid (22 g, 0.11 mol) was suspended in water, sodium hydroxide (4.33 g, 0.11 mol) and sodium sulfide hydrate (32 g) were added, and the mixture heated at reflux for 24 hours. After acidification with 5M hydrochloric acid the mixture was extracted with ethyl acetate. The extracts were dried over magnesium sulfate and evaporated under reduced pressure. The product from this reaction (1 g, 5.9 mmol) was dissolved in formic acid and heated at reflux in the presence of zinc (0.1 g) for 6 hours. The mixture was allowed to cool and was concentrated under reduced pressure. The residue was diluted with water and neutralised with saturated aqueous sodium hydrogen carbonate. Extraction with tetrahydrofuran and ethyl acetate (1:1) gave a pale yellow solid (0.48 g) that was purified on silica gel using a methanol dichloromethane gradient.

1. temperaturethe mixture heated
2. temperatureat reflux for 24 hours
3. extractionAfter acidification with 5M hydrochloric acid the mixture was extracted with ethyl acetate
4. dry with materialThe extracts were dried over magnesium sulfate
5. customevaporated under reduced pressure
6. customThe product from this reaction (1 g, 5.9 mmol)
7. temperatureheated
8. temperatureto cool
9. concentrationwas concentrated under reduced pressure
10. additionThe residue was diluted with water and neutralised with saturated aqueous sodium hydrogen carbonate
11. extractionExtraction with tetrahydrofuran and ethyl acetate (1:1)