反应详情

Powdered 4H-benzo[1,4]thiazin-3-one (7.0 g) was added cautiously, portionwise (over 20 minutes), to chlorosulfonic acid (15 mL), cooled in ice. After 1 hour the blue solution was allowed to warm to room temperature and it was heated at 45° C. for 2 hours, cooled and poured into ice. The solid was collected, washed with water, and hexane, and dried in vacuo, to give a white solid (7.0 g).

1. temperatureit was heated at 45° C. for 2 hours
2. temperaturecooled
3. additionpoured into ice
4. customThe solid was collected
5. washwashed with water, and hexane
6. customdried in vacuo