2-Methyl-5-hydroxypyridine → 5-Hydroxy-2-methylpyridine 1-oxide

Participants

Reaction Steps

5-Hydroxy-2-methylpyridine (25 g) was suspended in chloroform (500 ml) and treated with m-chloroperbenzoic acid (57 g of material described as 57-86% pure). After stirring for 1 hour the solution was dried with MgSO4 and poured onto a silica column. Elution with EtOAc to remove byproducts and then with 20-50% EtOH in EtOAc gave the product (27.7 g).

Provenance & Evidence