Dimethylformamide → HCID 68702328, compound

Participants

Reaction Steps

A solution of the pyridine N-oxide (309a) (21.12 g) in DMF (450 ml) was treated with potassium carbonate (26.2 g) and, after 30 mins., with methyl bromoacetate (16 ml), and stirred overnight. Solvent was evaporated, saturated brine (500 ml) added and the mixture extracted with chloroform (6×200 ml). The combined organic solution was dried and evaporated and the residue chromatographed (20% EtOH in EtOAc) to give product (18.5 g).

Provenance & Evidence