Ammonia → 3,6-Dichloropyridazin-4-amine

HRID 723531Notes

Reaction equation

HRID 723531 reaction equation
[Cl:1][C:2]1[N:3]=[N:4][C:5]([Cl:9])=[CH:6][C:7]=1Cl.[NH3:10]>>[NH2:10][C:7]1[CH:6]=[C:5]([Cl:9])[N:4]=[N:3][C:2]=1[Cl:1]

Participants

3

Reactant 2

HCID 222AmmoniaHCID 951233,4,6-Trichloropyridazine

Product 1

HCID 2984983,6-Dichloropyridazin-4-amine

Procedure

A suspension of 3,4,6-trichloropyridazine (prepared by the method of B. Kasnar et al, Nucleosides and Nucleotides, 1994, 13, 459) (10.0 g) in conc. aqueous ammonia (1 L) was heated at 75° C. for 16 h. The mixture was concentrated to a small volume and extracted several times with ethyl acetate. The extracts were washed with brine, dried and evaporated. The crude product was recrystallised from ethyl acetate to give the product (5.03 g).

Workup

  1. customprepared by the method of B
  2. concentrationThe mixture was concentrated to a small volume
  3. extractionextracted several times with ethyl acetate
  4. washThe extracts were washed with brine
  5. customdried
  6. customevaporated
  7. customThe crude product was recrystallised from ethyl acetate

Sources & evidence

ORD record
ord-cb541affb9eb4221b14af8d75c7103b1
Source dataset
uspto-grants-2006_11
Patent number
US07141564B2

Reaction notes

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