反应详情

Benzoyl peroxide (0.012 g) was added to a mixture of 4-(4-methylbenzoyl)-nitrobenzene (1.20 g) and N-bromosuccinimide (0.89 g) suspended in carbon tetrachloride (63 mL). The reaction mixture was refluxed under argon for 4 hours while illuminated with an incandescent lamp. The mixture was filtered, and the yellow solution containing the crude product was evaporated, chromatographed on silica gel, eluting with hexane/ethyl acetate, to give 4-(4-bromomethylbenzoyl)-nitrobenzene (1.79 g, 81%) as a white solid, m.p. 112.7–113.1° C.

1. temperatureThe reaction mixture was refluxed under argon for 4 hours
2. customwhile illuminated with an incandescent lamp
3. filtrationThe mixture was filtered
4. additionthe yellow solution containing the crude product
5. customwas evaporated
6. customchromatographed on silica gel
7. washeluting with hexane/ethyl acetate