Ammonia → HCID 9968829, compound

HRID 723603Notes

Reaction equation

HRID 723603 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:11]([C:20]([O:22]CC)=O)=[N:12][N:13]([CH2:17][CH2:18][OH:19])[C:14]=2[CH2:15][CH3:16])[CH:5]=[C:6]([Cl:8])[CH:7]=1.[NH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9][C:10]2[C:11]([C:20]([NH2:25])=[O:22])=[N:12][N:13]([CH2:17][CH2:18][OH:19])[C:14]=2[CH2:15][CH3:16])[CH:5]=[C:6]([Cl:8])[CH:7]=1

Participants

3

Reactant 2

HCID 222AmmoniaHCID 10200330Ethyl 4-[(3,5-dichlorophenyl)sulfanyl]-5-ethyl-1-(2-hydroxyethyl)-1H-pyrazole-3-carboxylate

Product 1

HCID 9968829HCID 9968829, compound

Procedure

A mixture of Example 46 (407 mg, 1.05 mmol) and 0.880 ammonia solution was heated at 90° C. in a sealed Reacti-vial (Trade Mark) for 18 hours. The precipitate was filtered off and washed with water (5 ml) to afford the title compound (273 mg) as a white solid, m.p. 214–216° C.

Workup

  1. filtrationThe precipitate was filtered off
  2. washwashed with water (5 ml)

Sources & evidence

ORD record
ord-9dbcece5a4c3463ab4c99d4e3fd5b3e1
Source dataset
uspto-grants-2006_11
Patent number
US07141585B2

Reaction notes

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