反应详情

3-Amino-4-iodobenzoic acid (13.35 g, 50.8 mmol) was added to MeOH (150 mL) and SOCl2 (4.8 mL, 65.8 mmol, 1.3 equivalent) was added. The mixture was refluxed for 3 h and then volatiles were removed under reduced pressure. The residue was co-evaporated three times with MeOH and dried in vacuo (15.23 g).

1. additionwas added
2. temperatureThe mixture was refluxed for 3 h
3. customvolatiles were removed under reduced pressure
4. customdried in vacuo (15.23 g)