Calcium Chloride → 5-Amino-3-methylpyridine-2-carbonitrile

HRID 723719Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 723719
[C:1]([C:3]1[C:8]([CH3:9])=[CH:7][C:6]([N+:10]([O-])=O)=[CH:5][N:4]=1)#[N:2].[Cl-].[Ca+2].[Cl-]>C(O)C.[Fe]>[NH2:10][C:6]1[CH:7]=[C:8]([CH3:9])[C:3]([C:1]#[N:2])=[N:4][CH:5]=1

Komponenten

5

Edukt 2

HCID 5284359Calcium ChlorideHCID 124040403-Methyl-5-nitropicolinonitrile

Produkt 1

HCID 218645665-Amino-3-methylpyridine-2-carbonitrileAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 23925IronKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

2-Cyano-3-methyl-5-nitropyridine (0.2 g, 1.23 mmol) was dissolved in 6 mL of 90% ethanol and calcium chloride (0.07g, 0.64 mmol) was added followed by iron powder (0.62g, 11.1 mmol, 325 Mesh). The heterogeneous mixture was stirred for one h. The mixture was filtered though Celite and concentrated to give compound 772B (0.13g, 81%) as a light-brown solid.

Aufarbeitung

  1. filtrationThe mixture was filtered though Celite
  2. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-3dd895a04d404cce8bf4521cd4360eb8
Quelldatensatz
uspto-grants-2006_11
Patentnummer
US07141578B2

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