反应详情

3-Chloro-2-cyano-5-nitropyridine (0.35g, 1.9 mmol), iron powder (0.56g, 10 mmol, 325 Mesh) and calcium chloride (0.06g, 0.55 mmol) were combined in 10 mL of 90% ethanol and as described in example 772B. Purification of the crude product via silica gel chomatography using 10% ether/CH2Cl2 as the eluent gives compound 775D (0.14g, 43%) as a light brown solid. HPLC: 95.5% at 1.69 min(YMC S5 ODS column) eluting with 10–90% aqueous methanol containing 0.2% phosphoric acid over a 4 min gradient monitoring at 220 nm. MS (ES): m/z 154.03 [M+H]+.

1. customPurification of the crude product via silica gel chomatography