참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | 2,3-Diaminotoluene | HCID 17593 | — |
| 반응물 | Thionyl Chloride | HCID 24386 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 4-Methyl-2,1,3-benzothiadiazole | HCID 2781262 | 90.7% |
반응 단계
To a solution of 2,3-diaminotoluene (5.0g, 40.9 mmol) in pyridine (40 mL) at 0° C. was added thionyl chloride (7.0 mL, 98.2 mmol) dropwise. The reaction mixture was stirred at 0° C. for 30 mins, then water (200 mL) was added. The solution was extracted with dicholomethane (2×250 mL). The combined organic layers were washed with brine, dried over Na2SO4 and concentrated in vacuo to give compound 839A (5.57g) as a dark brown liquid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07141578B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_11 |
|---|
| ORD ID | ord-973180f12602441d985451f98a8fdfbe |
|---|
| 출처 메모 | uspto-grants-2006_11 |
|---|
